Research At A Glance
Our Global Mission
Our goal is to improve the care of patients by translating scientific discoveries into meaningful clinical advances. We aim to develop new diagnostic approaches and innovative therapeutic strategies that enable earlier detection, more precise disease characterization, and more effective treatment.
Our research follows a continuous bench-to-bedside cycle. Starting with the identification of molecular targets, we validate their biological relevance and investigate their function through in vitro, ex vivo, and in vivo models. Insights gained from these studies guide the development of new diagnostic methods and therapeutic interventions. Observations from clinical application then inform further laboratory research, creating a dynamic feedback loop that continuously refines our understanding of disease.
I. Target Identification
Discovering disease-driving pathways and molecular targets through experimental and computational research
II. Target Assessment
Evaluating candidate targets to determine their biological relevance and therapeutic potential
III. Target Modelling
Testing disease mechanisms and therapeutic strategies in experimental and computational models
IV. Bench to Bedside Translation
Transforming scientific discoveries into diagnostic tools and treatments tested in clinical studies
V. Reverse Translation
Using insights from patients and clinical outcomes to refine hypotheses and guide new research
Fibrosis
We study the cellular and molecular drivers of fibrosis in rheumatic diseases, with a particular focus on systemic sclerosis. By combining patient-based research with advanced molecular and translational approaches, our lab seeks to uncover how immune dysregulation, stromal cells, and tissue remodeling lead to progressive organ scarring—and to use these insights to develop targeted strategies to prevent and reverse fibrosis.
Autoimmunity
We investigate the immune mechanisms that drive autoimmune and inflammatory processes in rheumatic diseases. By integrating patient-derived data with cutting-edge immunology and systems biology, our lab aims to identify the pathways that cause loss of immune tolerance and chronic tissue damage—and translate these discoveries into more precise, effective therapies for patients.
